Too much and too little adipose tissue can cause severe health implications. More commonly, too much adipose tissue leads to obesity, mainly from too much visceral fat. Obesity leads to a number of serious health problems. It increases the risk of developing type 2 diabetes as it causes the body to become resistant to insulin. This resistance results in high levels of blood sugar which is bad for health. Obesity also increases the chance of developing high blood pressure, high cholesterol levels, and an increased tendency for blood to clot leading to risk of heart attacks and stroke  . A lack of adipose tissue, lipodystrophy, can also cause similar problems and is seen with increasing frequency as a result of medication used to treat HIV/AIDS. In eating disorders, such as anorexia nervosa, the patients do not eat enough food to maintain their adipose tissue levels.  This means that they can lose a dangerous amount of body weight  . Anyone who is overweight and/or obese has some kind of insulin resistance, but diabetes only develops in those individuals who lack sufficient insulin secretion to match the degree of insulin resistance. Insulin in those people may be high, yet it is not enough to normalize the level of glycemia  . In order to develop insulin resistance and obesity, thereby causing type 2 diabetes, β-cells should not be able to compensate fully for decreased insulin sensitivity. 2 Buy Fat Burner Supplements Online  The non-esterified fatty acids (NEFAs) that are secreted from the adipose tissue in obese people may lead to the hypothesis that insulin resistance and β-cell dysfunction are most likely linked  .