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2. Yohimbe comes from the bark of a particular African tree. It may be burn off stubborn body fat  . Yohimbe is most often promoted in dietary supplements as effective in increasing muscle mass by boosting testosterone levels, accelerating weight loss, and increasing energy levels  . 2 Best Fat Burning Vitamin Supplements It is famous by enhancing blood flow and makes the oxidation of fatty acids easier  . Yohimbine acts on the adrenergic receptor system of fat cells, which regulate thermogenesis. The beta-subunits of the adrenergic receptors (targets of ephedrine) can be seen as stimulatory for fat loss as they increase the activity of the enzyme adenyl cyclase and subsequently cAMP levels  . The alpha-subunits are more suppressive of fat metabolism, in which their activation reduces activity of adenyl cyclase and reduces cAMP levels (specifically alpha-2)  . Yohimbine is a selective alpha-2 adrenergic receptor antagonist as it has a 45-fold higher affinity for the alpha-2 subunit than it does for the alpha-1 subunit, which inhibits activation of the suppressive set of receptors and preserves adenyl cyclase activity and the effects mediated via the beta receptors  . Yohimbine itself can potentially induce fat loss indirectly via the release of adrenaline which is an activator of beta-adrenergic receptors . Best 2022’s Fat Burner Supplement For Beginners However, this increase of adrenaline may fade with time reaching statistical insignificance 2 weeks after daily ingestion. Increases in plasma free fatty acids and the density of alpha-2 adrenergic receptors remain similar at both time points, suggesting that yohimbine selectively loses the spike in adrenaline but not direct receptor fat burning effects  .